Better Sleep May Hold Key to Managing Inflammatory Bowel Disease

Summary: Recent studies have highlighted the critical connection between sleep quality and the management of inflammatory bowel disease (IBD). Researchers have found that patients with active IBD experience significant disruptions in sleep, such as longer time to fall asleep, reduced deep sleep, and shorter total sleep duration. These sleep disturbances are closely linked to increased fatigue, which is a major symptom impacting the quality of life in IBD patients. By identifying distinct profiles of fatigue and sleep disturbances, healthcare providers can develop more targeted treatment strategies to improve patient outcomes.

Key Takeaways:

Link Between Sleep and IBD Activity: Patients with active IBD show significant sleep disturbances, including longer time to fall asleep, less deep sleep, and shorter overall sleep duration, which contribute to increased fatigue.
Complexity of Fatigue in IBD: Fatigue in IBD patients is multifaceted, with researchers identifying distinct profiles based on varying levels of sleep quality, IBD activity, depression, and anxiety, indicating that fatigue is not a uniform symptom.
Need for Targeted Interventions: Understanding the specific relationship between sleep disturbances and IBD activity opens the door for more targeted, sleep-focused interventions that could improve the quality of life for patients with IBD.

Helping people with inflammatory bowel diseases to get a better night’s sleep could help keep the condition at bay and improve their quality of life, say Flinders University and Flinders Medical Centre researchers, as they work to untangle the threads of the disease.

Inflammatory bowel disease (IBD) affects more than six million people worldwide, yet there is currently no known cause or cure. The best outcome for people diagnosed with the disease is to achieve remission and maintain a good quality of life, says researcher Alex Barnes, MD, FRACP, MPH, PhD, from the College of Medicine and Public Health and the IBD unit at Flinders Medical Centre, in a release.

Fatigue’s Link With IBD

Fatigue is one of the most common symptoms in people living with IBD, leading to a poor quality of life, and current treatments options are mostly ineffective.

“There is a complex relationship between sleep, fatigue, and IBD, with sleep disturbances common in people with IBD,” says Barnes in a release. “Sleep remains an underexplored area in IBD research, despite it being a significant cause of fatigue, and likely to influence other issues such as mental health conditions and aggravate IBD activity. Understanding the relationship between sleep, IBD, and the causes of fatigue could lead to more effective treatment strategies and is crucial for managing the diseases effectively.”

IBD is a term for two diseases (Crohn’s disease and ulcerative colitis) that are incurable, chronic relapsing-remitting inflammatory conditions affecting the digestive tract, leading to debilitating symptoms and poor quality of life.

Determining Objective Sleep Measurements

The study, published in Digestive Diseases and Sciences, sought to demonstrate objective changes in sleep patterns due to IBD activity.

“Existing studies show conflicting information on the relationship between IBD and sleep. We wanted to address this by using objective measures of both sleep quality and IBD activity to better understand the relationship between the two,” says Barnes in a release.

The study used the “gold standard” of sleep assessment, polysomnography, on people confirmed to have active IBD who also completed a survey on sleep quality, IBD activity, depression, and anxiety.

“We found that people with active IBD have distinct changes in their sleep patterns compared to those with inactive IBD. They took longer to fall asleep, spent less time in deep sleep, and had a shorter total sleep time,” says Barnes in a release. “With a more comprehensive understanding of the relationship between sleep and IBD, we hope to be able to address sleep-related fatigue and improve patients’ quality of life.”

Fatigue: More Complex Than Previously Thought

Another recent study by Flinders University and Flinders Medical Centre, published in BMC Gastroenterology, explored the concept of “subcategories” of fatigue by collecting data from over 500 people with IBD and analyzing the relationships between factors such as fatigue, sleep quality, anxiety, depression, and IBD activity.

“In the past, fatigue might have been viewed as a single, uniform symptom. However, we now know that fatigue is much more complex and can manifest in different ways, depending on each person’s unique circumstances,” says Barnes in a release.

The researchers grouped people with IBD into four profiles based on their symptoms differing by sleep quality, IBD activity, depression, and anxiety.

The low fatigue profile (23%) had mild levels of fatigue and low levels of depression and anxiety; the poor mental health profile (14%) was characterized by severe anxiety and depression; the active IBD profile (31%) had high levels of IBD activity and poor sleep quality, but their mental health was only mildly affected. The at-risk profile (33%), being the largest profile, had mild levels of depression and anxiety and moderate levels of fatigue.

“Fatigue is common in people with IBD and has been associated with increased symptoms of IBD, poor sleep quality, depression, and anxiety,” says Barnes in a release. “By identifying these distinct profiles of fatigue, healthcare providers can develop more targeted treatment strategies and improve patient outcomes.”

Recommendations for Future Treatments

Based on these latest studies, researchers recommend further investigations into quality of sleep and levels of fatigue to improve future treatments for people living with IBD.

“We are working to untangle the threads and strands of inflammatory bowel diseases so we can better understand how to treat them,” says co-author Reme Mountifield. “By identifying the underlying mechanisms and causes of the diseases, we can design bespoke therapies to address specific aspects of the disease process such as sleep, which can ultimately improve patients’ outcomes and quality of life.”