Summary: Axsome Therapeutics, in collaboration with Narcolepsy Network, performed the CRESCENDO study, revealing ongoing problems faced by narcolepsy sufferers inspite of cure. The examine associated 203 grownup people diagnosed with narcolepsy form 1, highlighting persistent signs these kinds of as cataplexy, extreme daytime sleepiness, and cognitive impairment. Inspite of receiving pharmacotherapy, clients claimed important burdens on their qualified, social, and day-to-working day lives.
Key Details:
- Irrespective of obtaining therapy, a bulk of narcolepsy people documented persistent signs or symptoms, together with cataplexy, extreme daytime sleepiness, and cognitive impairment.
- The survey, conducted in partnership with Narcolepsy Network, involved 203 adult sufferers identified with narcolepsy type 1, offering insights into the affected individual practical experience and the stress of health issues.
- Axsome Therapeutics ideas to present in depth outcomes from the CRESCENDO survey at future scientific meetings.
Axsome Therapeutics introduced topline success from the CRESCENDO (Characterizing Affected individual Perspectives on Unmet Requirements in Narcolepsy) study of people with narcolepsy style 1 getting treatment, demonstrating high rates of persistent signs or symptoms and considerable patient stress despite currently being on present-day treatment options.
CRESCENDO was conducted in partnership with Narcolepsy Network, a countrywide nonprofit affected individual help organization for men and women with narcolepsy, idiopathic hypersomnia, and relevant slumber disorders.
The CRESCENDO survey provided 203 adult clients diagnosed with narcolepsy sort 1, who collectively have additional than 2,600 a long time of lived working experience with the sleep condition, to fully grasp their experience and journey, to measure disease signs and symptoms which include cognitive impairment while on remedy, and to evaluate the burden of illness, comorbidities, and unmet requires and issues people confront.
To quantify crucial features of the narcolepsy patient encounter, CRESCENDO used patient-documented actions and validated scales, which includes the Epworth Sleepiness Scale to assess abnormal daytime sleepiness and the British Columbia Cognitive Issues Inventory to assess cognitive purpose.
All patients taking element in the survey have been at the moment going through cure for narcolepsy style 1. The most prevalent remedies were wake-marketing agents (about 53% of surveyed sufferers), oxybates (47%), and stimulants (42%).
Even with getting treatment method, the bulk of narcolepsy patients ongoing to expertise indicators. Cataplexy was noted by 77% of individuals even though on their current treatment method regimen. Abnormal daytime sleepiness, assessed using the Epworth Sleepiness Scale (scores > 10), was observed in 64% of patients in spite of acquiring present-day therapies. Cognitive impairment, assessed using the British Columbia Cognitive Grievances Inventory (scores ≥5), was observed in 74% of sufferers. Despair and nervousness were being knowledgeable by about 45% and 57% of sufferers respectively.
“Unfortunately, narcolepsy is underrecognized and underdiagnosed by the clinical community, and its burden of sickness is not extensively comprehended or appreciated, which is why the CRESCENDO study is these types of an important move ahead in boosting awareness of narcolepsy and its influence on individual life, and in supplying voice to the hundreds of people today residing with this debilitating disorder,” suggests Karl Doghramji, MD, FAASM, professor of psychiatry, neurology, and drugs and health-related director of the Jefferson Snooze Conditions Centre at Thomas Jefferson College, in a release.
Axsome options to present the in depth success of the CRESCENDO survey at approaching scientific conferences.
Essential Topline Conclusions from the CRESCENDO Survey
Patient demographics
- Study respondents consisted of a whole of 203 adults, aged 18-82 yrs (imply 41 many years) with a analysis of narcolepsy Variety 1, all of whom experienced working experience with US Food stuff and Drug Administration-authorized treatment plans for their narcolepsy.
Existing remedies and comorbidities
Topics were being obtaining pharmacotherapy for narcolepsy.
- The most widespread narcolepsy-particular treatment plans ended up wake-advertising agents (53% of surveyed people), oxybates (47%), and stimulants (42%).
- 37% of participants had been diagnosed with depression, of which 80% have been taking treatment to regulate their melancholy.
- 37% of contributors were diagnosed with anxiousness, of which 72% were being using medicine to deal with their anxiousness.
Prevalence of narcolepsy indicators although on treatment
- Cataplexy was reported by 77% of individuals though on their latest treatment method program.
- Extreme daytime sleepiness, assessed applying the Epworth Sleepiness Scale (scores > 10), was noticed in 64% of individuals irrespective of acquiring latest therapies.
- Cognitive impairment, assessed utilizing the British Columbia Cognitive Problems Inventory (scores ≥5), was noticed in 74% of patients on cure.
- 68% rated their capacity to focus as very poor, pretty very poor, or average.
Cataplexy impacts on daily lifetime
- 65% of individuals at the moment encountering cataplexy reported that cataplexy burdens their experienced everyday living (e.g. job, university), in spite of therapy
- 60% of members currently suffering from cataplexy noted that cataplexy burdens their social everyday living, inspite of procedure.
- 50% of individuals at this time suffering from cataplexy documented that cataplexy burdens their day-to-day lifestyle, inspite of cure
- 64% and 68% of patients encountering cataplexy reported being humiliated by falling down and slurred speech, respectively, irrespective of cure.
The study was executed in between Oct and December 2023.
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